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Industries · Pharma & Life Sciences

The integration platform that doesn’t cost you a 483.

Regulated life-sciences workloads run on integrations that have to survive an audit on no notice. 21 CFR Part 11 e-signature lineage, DSCSA serialization for pharma supply chain, CDISC SDTM/ADaM for clinical, GxP validated environments, and HL7 v2 for site integrations - all with the prior-state preservation and chain-of-custody discipline that FDA, EMA, and PMDA expect.

The realities

What integration looks like inside a regulated life-sciences estate.

Reality 01
Every change has consequences

A config tweak isn’t a config tweak — it’s a regulated change-control event that has to be requested, approved, executed, witnessed, and archived. The integration platform owns half the change-control surface.

Reality 02
Validation cycles are 9 months

IQ, OQ, PQ for every system touching GxP data. The integration layer can’t hide from validation just because it’s "infrastructure" — auditors check it specifically.

Reality 03
Serialization is non-negotiable

DSCSA, EU FMD, Russia CRPT — each unit-level serial has to flow through manufacturing, packaging, distribution, and dispensing with bidirectional verification at every hand-off.

Reality 04
Clinical + commercial don’t mix

CDISC SDTM/ADaM in the clinical zone. SAP / HL7 / EDI in commercial. The two estates must coexist with separation enforced through identity, network, and audit boundaries.

21 CFR Part 11 · audit demonstrator

A regulated change, with its full chain of custody.

A representative batch-release decision moving through Art2link - rendered as the operator sees it in the audit ledger. Every action carries its prior state, its reason, the e-signature, and a tamper-evident hash. This is the document an FDA inspector asks for; we produce it on demand.

Audit ledger · Batch LOT-2026-D8841 · Active pharmaceutical ingredient
Batch release · GxP-validated change
01Entry
QC review completed 2026-05-12 · 09:14:32 UTC · system Art2link · LIMS bridge
Action Routine QC test panel completed against batch LOT-2026-D8841. All 14 test results imported from LabWare LIMS via HL7 v2.5.1 OUL^R22 result message.
Prior state Status: AWAITING_QC · 0 of 14 results
New state Status: QC_COMPLETE · 14 of 14 results · all in spec
Performed byLabWare system → LIMS bridge
E-signatureN/A — system event
Record hashsha256:7a4f…b2c9
02Entry
QC manager approves batch for release 2026-05-12 · 11:48:07 UTC · system Art2link · QMS interface
Reason for change Batch meets all release criteria per SOP-QC-2412 v3.1. Test panel within acceptance limits. No deviations open against this batch.
Prior state Status: QC_COMPLETE · disposition: PENDING
New state Status: QC_APPROVED · disposition: PROVISIONAL_RELEASE
Performed byMaria Chen · QC Manager · empId QC-441
E-signaturePIN + 2FA · TOTP verified
Record hashsha256:e02d…91af · chain:OK
03Entry
Qualified Person releases batch for commerce 2026-05-12 · 14:22:51 UTC · system Art2link · ERP-MES bridge
Reason for change Final disposition by Qualified Person per EU GMP Annex 16 and 21 CFR Part 211. Batch records reviewed: master record (MBR-2412), executed record (EBR-D8841), QC test panel, raw material lot certificates. Batch fit for market.
Prior state Status: QC_APPROVED · disposition: PROVISIONAL_RELEASE
New state Status: RELEASED · disposition: COMMERCIAL · DSCSA serials activated
Performed byDr. Anders Sørensen · QP · empId QP-007
E-signaturePIN + 2FA + biometric · WebAuthn
Record hashsha256:c1be…334d · chain:OK
04Entry
Downstream system propagation 2026-05-12 · 14:23:04 UTC · system Art2link · propagation pipeline
Action Release decision propagated to downstream systems: SAP S/4HANA finance & inventory (IDoc DELVRY07), warehouse (HighJump WMS), DSCSA repository (EPCIS 1.2 event), TraceLink network for trading-partner verification.
Systems updated SAP: pending · WMS: pending · DSCSA: pending
New state SAP · WMS · DSCSA · TraceLink — all confirmed
Performed byArt2link propagation pipeline · automated
E-signatureSystem signature · derived from entry 03
Record hashsha256:f0a7…68bb · chain:OK
Every entry is immutable. Records are written to append-only storage with per-entry SHA-256 hashing. Each entry hashes its own contents plus the previous entry’s hash, forming an integrity chain that detects any tampering. The audit ledger is exportable to FDA-compliant PDF on request and can be granted read-only inspector access without exposing the underlying systems.
Clinical & commercial stack

The regulated and commercial systems an L/S estate runs.

Manufacturing & QC · GxP

  • SAP ME / DMC regulated MES
  • Rockwell PharmaSuite
  • Werum PAS-X regulated MES
  • LabWare LIMS
  • STARLIMS
  • OSIsoft PI historian

Clinical & trials · CDISC

  • Veeva Vault Clinical
  • Medidata Rave EDC
  • Oracle Clinical / RDC
  • Argus Safety
  • SAS Clinical
  • CDISC SDTM/ADaM datasets

Supply chain & serialization · DSCSA · FMD

  • SAP S/4HANA · ATTP serialization
  • TraceLink network
  • rfxcel · Antares Vision
  • EPCIS 1.2 events
  • EU Hub · NMVS verification
  • GS1 GTIN / SSCC labels
Compliance posture

The regulatory surface an integration platform owns.

Art2link runs in your Azure subscription - clinical, GxP, and PHI data never leave your tenant. GxP-validated deployment topology (IQ/OQ/PQ scripts available). Audit retention configurable to FDA 21 CFR Part 211 (10+ years) requirements. EU GMP Annex 11 controls supported. Inspector read-only access to audit logs available on request.

21 CFR Part 11E-signature + audit
EU GMP Annex 11Computerized systems
DSCSAPharma serialization
EU FMDFalsified medicines
Tenant-scopedRuns in your Azure
SOC 2 Type 1In progress
In production

Life-sciences estates already running on Art2link.

A global pharmaceutical manufacturer connected 17 production sites across 6 countries for DSCSA + EU FMD serialization on Art2link - passing two FDA inspections and one EMA inspection in the first 18 months without a single 483 observation on the integration layer.

Pharmaceutical · DSCSA · EU FMD · multi-country

A specialty biotech consolidated 9 LIMS systems, an SAP ERP, and a Veeva QMS into one Art2link runtime - cutting the audit-trail compilation time for batch release records from 4 days to under 20 minutes.

Specialty biotech · GxP-validated · multi-LIMS
GxP compliance review

Walk a real regulated flow with our team.

30 minutes with a senior architect who has shipped in regulated pharma. Bring a compliance question (DSCSA, Part 11, validation strategy) or a flow you want to walk; leave with a tailored reference architecture.