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Solutions · HL7 & FHIR · Laboratory Integration

The integration backbone behind modern reference labs.

Art2link ESB connects your LIS, every analyzer on the floor, and the ordering EHRs upstream - translating HL7 v2.x orders and ORU^R01 results into compliant FHIR R4 / R5 resources, with full per-message audit. Built by the original BizTalk architects. Runs entirely inside your Azure tenant. PHI never leaves.

  • Built by original BizTalk architects
  • ·
  • HIPAA-aligned, tenant-scoped
  • ·
  • Microsoft Solutions Partner
Result transformation

A live ORU^R01 → FHIR Observation. Hover either side to trace the mapping.

A glucose result coming off a Roche cobas chemistry analyzer, leaving your LIS as an HL7 v2.5.1 ORU^R01 message, and arriving at the ordering EHR as a FHIR R4 Observation resource. Hover any HL7 segment on the left and its mapped FHIR property highlights on the right - bidirectional.

HL7 v2.5.1 · ORU^R01 From: LIS / Roche cobas analyzer · MLLP over TLS 1.3
FHIR R4 · Observation To: ordering EHR · HTTPS / SMART on FHIR
MSH|^~\&|LIS|REFLAB|EHR|HOSP|20260514143211||ORU^R01|L260514-0421|P|2.5.1
PID|||MRN12345^^^EPIC^MRN||DOE^JOHN^M||19751023|M
OBR|1|||CBC^Complete Blood Count
OBX|1|NM|2345-7^Glucose^LN||92|mg/dL|70-100|N|||F
{
  "resourceType": "Observation",
  "id": "obs-L260514-0421",
  "status": "final",
  "category": [{
    "coding": [{ "code": "laboratory" }]
  }],
  "code": {
    "coding": [{
      "system": "http://loinc.org",
      "code": "2345-7",
      "display": "Glucose"
    }]
  },
  "subject": { "reference": "Patient/MRN12345" },
  "valueQuantity": {
    "value": 92,
    "unit": "mg/dL",
    "system": "http://unitsofmeasure.org"
  },
  "referenceRange": [{
    "low":  { "value": 70 },
    "high": { "value": 100 }
  }],
  "interpretation": [{
    "coding": [{ "code": "N" }]
  }]
}
Hover any HL7 segment (e.g. OBX, PID, MRN12345) and its mapped FHIR property highlights on the right. The mapping is bidirectional - hover the right side to find the source HL7 segment.
Lab operations console · live preview

Every accession, every result, observable end-to-end.

What your laboratory operations team sees in production - not a screenshot, but the same structure rendered into the page so you can feel how it behaves. Hover any row to surface the accession ID; the status dot tells you where each message stands in the pipeline.

Inbound clinical traffic · last 60 seconds · 6 of 2,419 shown

Live
Time Source · System Type Accession · Patient Status
14:32:11 Roche cobas · LIS ORU^R01 L260514-0421 · MRN12345 FHIR R4 msg00421
14:31:58 Epic Beaker · order ORM^O01 L260514-0420 · MRN98701 Routed msg00420
14:31:45 Sysmex XN · LIS ORU^R01 L260514-0419 · MRN24508 Transforming msg00419
14:31:28 Abbott Architect · LIS ORU^R01 L260514-0418 · MRN77104 FHIR R4 msg00418
14:31:09 Illumina NovaSeq · NGS OUL^R22 L260514-0417 · QC pending QC review msg00417
14:30:47 Oracle Cerner · order ORM^O01 L260514-0416 · MRN31200 Routed msg00416
Message taxonomy

Every HL7 event your lab actually moves - mapped to the FHIR resources the EHR consumes.

HL7 v2.x lab & clinical events

  • ORM^O01Order
  • OML^O21Lab order
  • ORU^R01Result
  • OUL^R22Unsolicited lab
  • ADT^A01Admit
  • ADT^A04Register
  • ADT^A08Update info
  • MDM^T02Document
  • SIU^S12Schedule
  • VXU^V04Immunization
  • DFT^P03Charge
  • BAR^P01Billing

FHIR R4 / R5 diagnostic resources

  • DiagnosticReport
  • Observation
  • Specimen
  • ServiceRequest
  • MolecularSequence
  • Patient
  • Encounter
  • Practitioner
  • Coverage
  • DocumentReference
  • Condition
  • MedicationRequest
USCDI v3 + LOINC + SNOMED CT All US Core Data for Interoperability v3 profiles supported. LOINC codes preserved and validated on every OBX segment. SNOMED CT, RxNorm, ICD-10-CM, and UCUM unit normalization in line. IHE LAB-TF profiles (LCC, LBL, LAW) and PIX/PDQ/XDS supported on top.
Instrument & LIS coverage

Six disciplines. Every analyzer on the floor. Already wired.

Validated profiles and pre-built adapters for the analyzers and LIS platforms that actually live in production labs. ASTM E1394, HL7 v2.5.1 over MLLP/TLS, POCT1-A2 for point-of-care, plus native LIS APIs where vendors publish them.

01 · Chemistry

Routine & specialty chemistry

  • Roche cobas pro / 8000
  • Abbott Alinity c
  • Siemens Atellica CH
  • Beckman AU5800
  • Ortho Vitros XT
02 · Hematology

CBC, coag, flow

  • Sysmex XN-Series
  • Beckman DxH 900
  • Abbott Alinity h
  • Siemens ADVIA
  • BD FACSLyric
03 · Immunoassay

Endocrine, tumor, cardiac

  • Abbott Architect
  • Roche cobas e
  • Siemens Atellica IM
  • DiaSorin LIAISON
  • Ortho Vitros ECi
04 · Microbiology

ID, AST, MALDI-TOF

  • bioMérieux VITEK 2
  • BD Phoenix M50
  • Bruker MALDI Biotyper
  • BD BACTEC FX
  • Cepheid GeneXpert
05 · Molecular · NGS

Sequencing & PCR

  • Illumina NovaSeq / NextSeq
  • Thermo Ion GeneStudio
  • Roche cobas 6800
  • Hologic Panther Fusion
  • QIAGEN QIAstat-Dx
06 · Blood bank · Transfusion

Type, screen, cross-match

  • Ortho Vision Max
  • Immucor NEO Iris
  • Bio-Rad IH-1000
  • Grifols Erytra
  • Werfen ACL TOP
LIS platforms supported. Cerner Millennium PathNet · Epic Beaker · Sunquest · SCC SoftLab · Orchard Harvest · LigoLab · Apollo LIMS · Aspyra CyberLAB · Meditech LIS · Halfpenny Technologies. Custom LIS via HL7 v2.x over MLLP, REST, or scheduled file drop. MLLP / TLS 1.3 ASTM E1394 POCT1-A2 FHIR R4 / R5 SMART on FHIR
Ordering EHR coverage

Every EHR sending you orders. Every EHR consuming your results.

Validated adapters for the EHRs upstream of your lab - whether they're sending ORM/OML orders or receiving FHIR DiagnosticReport resources. Hover any vendor to see specific protocol coverage.

Epic

MyChart · Bridges · Care Everywhere
HL7 v2.5.1 · FHIR R4 · Care Everywhere
  • HL7 v2.5.1 over MLLP and TLS
  • FHIR R4 endpoints via Bridges
  • Care Everywhere XCA/XDS document share
  • Carequality & eHealth Exchange ready
  • OAuth 2.0 (SMART on FHIR)
Hover to expand

Oracle Cerner

Millennium · HealtheIntent · CareAware
HL7 v2.5 · FHIR R4 · CCDA
  • HL7 v2.5 over MLLP, FTPS
  • FHIR R4 with US Core profiles
  • CCDA continuity-of-care documents
  • HealtheIntent population queries
  • OAuth 2.0 client-credentials
Hover to expand

Allscripts / Veradigm

Sunrise · TouchWorks · Practice Fusion
HL7 v2.4 / 2.5 · FHIR R4 · Open API
  • HL7 v2.4 and v2.5 over MLLP
  • FHIR R4 read-only and write-back
  • Allscripts Open API (Unity)
  • Sunrise Clinical Manager integration
  • Practice Fusion FHIR endpoints
Hover to expand

Athena · NextGen · eClinicalWorks

Athenahealth · NG Enterprise · eCW
HL7 v2 · FHIR R4 · Native APIs
  • Athena AthenaOne FHIR R4 + native API
  • NextGen Enterprise HL7 v2 + FHIR
  • eClinicalWorks HL7 v2 + Open Interfaces
  • Greenway Intergy & PrimeSuite supported
  • OAuth 2.0 SMART on FHIR
Hover to expand

Long tail: Meditech Expanse, Allscripts dbMotion, Sunrise CIS, Greenway PrimeSuite, McKesson Paragon, NextGen Healthcare, Practice Fusion, CPSI Evident, Harris MEDITAB, AdvancedMD, DrChrono, Kareo, Amazing Charts. The connector library covers the long tail; the adapters above represent the highest-volume customer estates.

Lab compliance posture

The posture your compliance officer, CAP inspector, and CISO already trust.

Art2link ESB runs entirely inside your own Azure subscription - PHI, PII, and ePHI never leave your tenant. Controls include immutable audit logging, encryption at rest and in transit, Key Vault-backed secrets, Entra ID-secured operator access, configurable retention, and full message replay for CAP / CLIA inspection windows.

Tenant-scoped
Your Azure subscription
Art2link is deployed into the customer's Azure subscription. Message data, audit logs, and configuration never leave your tenant. No multi-tenant control plane handling your PHI.
Encryption
TLS 1.3 + at-rest keys
TLS 1.3 for every external connection. mTLS where required. At-rest encryption via Azure-managed keys or BYOK through Key Vault. Cipher suites configurable per route.
Entra ID
Identity & least-privilege
Entra ID OIDC for operator sign-in. Managed identity for outbound calls. Per-artifact RBAC. SCIM 2.0 for user provisioning. Conditional access policies inherited from your tenant.
CAP / CLIA-ready
Full message replay
Every inbound and outbound message retained per your retention policy. Replay any accession on demand - the audit your CAP inspector wants without ad-hoc scripts.
USCDI v3
US Core + LOINC
All USCDI v3 data classes supported as FHIR R4 US Core profiles. LOINC codes preserved across the transformation. ONC Cures Act and TEFCA-aligned.
IHE LAB-TF
LCC · LBL · LAW
Implements IHE Laboratory Technical Framework profiles: Laboratory Code Sets (LCC), Laboratory Barcode Labeling (LBL), Laboratory Analytical Workflow (LAW). PIX/PDQ/XDS for patient ID. Carequality compatible.
In production

Lab volume that doesn’t flinch.

A national reference lab routes 180,000+ result messages/day off 40+ analyzer instruments through Art2link - ORU, OML, OUL - into FHIR R4 DiagnosticReports delivered to ordering Epic and Cerner instances with p99 transform under 50 ms.

Reference lab · multi-instrument estate · FHIR R4 out

A specialty molecular lab cut 11 weeks of integration work to 9 days by replacing a custom Mirth + script estate with Art2link, while standing up a FHIR R5 MolecularSequence endpoint for the partner network - no PHI ever leaving the customer’s Azure tenant.

Specialty / molecular lab · NGS + clinical · FHIR R5
Free lab integration assessment

We’ll map your analyzers, your LIS, and your downstream EHRs. Written report in one week.

What you get

An integration readiness report for your lab estate.

An Art2link senior healthcare-integration architect inventories your analyzer interfaces, your LIS topology, and your downstream HL7 / FHIR consumers, and returns a written readiness assessment: gaps in ASTM / HL7 coverage, FHIR R4 / R5 resource mapping plan for DiagnosticReport, PHI / ePHI handling exposure, and a wave plan for cutover.

  • Written assessment within 5 business days of intake
  • Reviewed by a senior healthcare-integration architect - not a generalist
  • No cost. NDA on file before any interface inventory is reviewed.
  • Format your compliance officer can share internally without redaction
We reply within one business day to confirm intake.
Not ready for the assessment?

Try the Starter Plan in your Azure tenant, free.

Install the free Starter Plan from Azure Marketplace and route a sample analyzer feed into FHIR R4 in your own subscription. PHI never leaves your tenant. No credit card.